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Previous Volume 332:1036 April 13, 1995 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Nitric oxide is a gas neurotransmitter involved in multiple physiologic and pathologic processes.¹ We report a case in which the use of nitric oxide for the treatment of pulmonary hypertension after lung transplantation may have caused extensive lower motor neuron disorder.

Nitric oxide activates guanylate cyclase, which is a transduction mechanism for the glutamatergic N-methyl-d-aspartate (NMDA) receptor. Glutamate and other excitatory amino acids can damage neurons if they persistently or excessively stimulate their receptors. They have been implicated in degenerative motor neuron diseases such as amyotrophic lateral sclerosis and Guam motor neuron . . . [Full Text of this Article]

References

Related Letters:

Nitric Oxide and Motor Neuron Disease
Greenfield L. J., Albers J. W.
Extract | Full Text  
N Engl J Med 1995; 333:522-523, Aug 24, 1995. Correspondence

This article has been cited by other articles:

• Greenfield, L. J., Albers, J. W. (1995). Nitric Oxide and Motor Neuron Disease. NEJM 333: 522-523 [Full Text]