FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 332:1293-1294 May 11, 1995 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Most physicians accept that hyperglycemia makes an important contribution to the complications of diabetes mellitus involving small and large vessels, but whether hyperglycemia alone is sufficient to explain diabetic vascular disease remains controversial. Epidemiologic evidence suggests that the end-organ response to exposure to diabetes, defined as the duration of hyperglycemia multiplied by its degree, differs in different vascular beds. Given time, retinopathy appears to develop in virtually all patients with insulin-dependent diabetes mellitus (IDDM), but this is not the case for nephropathy or cardiovascular disease.¹ The cumulative risk of albuminuria in patients with IDDM is about 35 percent, no matter . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Reiner, A., Del Mar, N., Meade, C. A., Yang, H., Dragatsis, I., Zeitlin, S., Goldowitz, D. (2001). Neurons Lacking Huntingtin Differentially Colonize Brain and Survive in Chimeric Mice. J. Neurosci. 21: 7608-7619 [Abstract] [Full Text]  
• Ravid, M., Brosh, D., Ravid-Safran, D., Levy, Z., Rachmani, R. (1998). Main Risk Factors for Nephropathy in Type 2 Diabetes Mellitus Are Plasma Cholesterol Levels, Mean Blood Pressure, and Hyperglycemia. Arch Intern Med 158: 998-1004 [Abstract] [Full Text]  
• Angulo, J., Sanchez-Ferrer, C. F., Peiro, C., Marin, J., Rodriguez-Manas, L. (1996). Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin: Possible Mechanisms Involved. Hypertension 28: 583-592 [Abstract] [Full Text]