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Previous Volume 332:1305-1306 May 11, 1995 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Since we found evidence of a threshold for the effect of hyperglycemia on the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus (IDDM),¹ we used published data to examine whether there was a similar pattern for diabetic retinopathy. In the Diabetes Control and Complications Trial (DCCT),² the incidence of the development or progression of retinopathy in the group assigned to intensive treatment fluctuated around 2.0 per 100 person-years in the nine deciles of the hemoglobin A_1c distribution below 8.5 percent and rose to 7.0 per 100 person-years in the highest decile, consistent with a threshold value . . . [Full Text of this Article]

References

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• Angulo, J., Sanchez-Ferrer, C. F., Peiro, C., Marin, J., Rodriguez-Manas, L. (1996). Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin: Possible Mechanisms Involved. Hypertension 28: 583-592 [Abstract] [Full Text]  
• Chaturvedi, N., Fuller, J. H., The EURODIAB IDDM Complications Study Group, , Krolewski, A. S., Warram, J. H. (1995). Glycosylated Hemoglobin and the Risk of Microalbuminuria in Insulin-Dependent Diabetes Mellitus. NEJM 333: 940-941 [Full Text]  
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