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Previous Volume 332:86-90 January 12, 1995 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The major histocompatibility complex (MHC) class II molecules are composed of two polypeptide chains ( and ). In humans the three distinct isotypes are designated HLA-DR, DP, and DQ. The different isotypes serve similar functions, and their expression on cells is regulated in coordinated fashion.¹ MHC class II molecules are expressed on the surface of certain cells of the immune system, such as monocytes and macrophages, B cells, and dendritic cells, where they play an important part in the immune response.²

MHC class II deficiency is an autosomal recessive disease characterized by cellular and humoral immunodeficiency.³ Family studies show that . . . [Full Text of this Article]

Case Report

Methods

Results

Discussion

Source Information

From the Institute of Immunology, University of Vienna (H.M.W., I.H., H.G., V.T., H.E., M.B.F., M.M.E.), and the Pediatric Department, Wilhelminenspital of the City of Vienna (S.F.) — both in Vienna, Austria.

Address reprint requests to Dr. Eibl at the Institute of Immunology, University of Vienna, Borschkegasse 8A, A-1090 Vienna, Austria.

References

This article has been cited by other articles:

• Wiszniewski, W., Fondaneche, M.-C., Le Deist, F., Kanariou, M., Selz, F., Brousse, N., Steimle, V., Barbieri, G., Alcaide-Loridan, C., Charron, D., Fischer, A., Lisowska-Grospierre, B. (2001). Mutation in the Class II trans-Activator Leading to a Mild Immunodeficiency. J. Immunol. 167: 1787-1794 [Abstract] [Full Text]  
• Lennon-Dumenil, A.-M., Barbouche, M.-R., Vedrenne, J., Prod'Homme, T., Bejaoui, M., Ghariani, S., Charron, D., Fellous, M., Dellagi, K., Alcaide-Loridan, C. (2001). Uncoordinated HLA-D Gene Expression in a RFXANK-Defective Patient with MHC Class II Deficiency. J. Immunol. 166: 5681-5687 [Abstract] [Full Text]  
• Bogardus, S. T. Jr, Concato, J., Feinstein, A. R. (1999). Clinical Epidemiological Quality in Molecular Genetic Research: The Need for Methodological Standards. JAMA 281: 1919-1926 [Abstract] [Full Text]  
• Villard, J., Lisowska-Grospierre, B., van den Elsen, P., Fischer, A., Reith, W., Mach, B. (1997). Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency. NEJM 337: 748-753 [Abstract] [Full Text]  
• Hauber, I., Wolf, H. M., Eibl, M. M., Wahn, V. (1996). More on MHC Class II Deficiency. NEJM 335: 977-978 [Full Text]  
• Mach, B. (1995). MHC Class II Regulation -- Lessons from a Disease. NEJM 332: 120-123 [Full Text]