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The determinants and consequences of the human immunodeficiency virus (HIV) go beyond virology. The AIDS epidemic has challenged contemporary notions of infectious disease and immunology, health and health care, sex, and science. Like all chronic illnesses, AIDS profoundly affects people in every aspect of their lives. In addition to facing a severe health challenge, persons infected with HIV must also respond to complicated social, economic, and legal conditions. We must move forward in our approach to understanding, preventing, and treating AIDS by considering clinical care and clinical research in the broad context of economic, social, cultural, and political realities. AIDS
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