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Previous Volume 332:1443-1444 May 25, 1995 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Not so long ago, therapies that led to a survival advantage in randomized trials were quickly endorsed and adopted. The costs required to achieve the clinical benefit were of only minimal interest to the primary decision makers — physicians seeking the best outcomes for their patients. And in that era there would have been little controversy over whether tissue plasminogen activator (t-PA) is a more effective thrombolytic agent than intravenous streptokinase. Laboratory and clinical studies show that t-PA opens coronary arteries occluded by thrombus more rapidly than streptokinase,¹ and the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded . . . [Full Text of this Article]

References

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Is the Use of t-PA as Compared with Streptokinase Cost Effective?
Rose E. A., Armentano R., Favaloro R. G., Mark D. B.
Extract | Full Text  
N Engl J Med 1995; 333:1009-1010, Oct 12, 1995. Correspondence

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• O'Brien, B. J., Heyland, D., Richardson, W. S., Levine, M., Drummond, M. F., for the Evidence-Based Medicine Working Group, (1997). Users' Guides to the Medical Literature: XIII. How to Use an Article on Economic Analysis of Clinical Practice B. What Are the Results and Will They Help Me in Caring for My Patients?. JAMA 277: 1802-1806 [Abstract]  
• Rose, E. A., Armentano, R., Favaloro, R. G., Mark, D. B. (1995). Is the Use of t-PA as Compared with Streptokinase Cost Effective?. NEJM 333: 1009-1010 [Full Text]