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Previous Volume 332:1520-1521 June 1, 1995 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Castleberry and coworkers (Dec. 22 issue)¹ report that isotretinoin (13-cis-retinoic acid) may induce long-term responses in some patients with juvenile chronic myelogenous leukemia. In this study of 10 children, isotretinoin induced complete remissions in 2, partial remissions in 3, and a minimal response in 1; the remaining 4 patients had progressive disease. Among the seven patients who did not undergo subsequent bone marrow transplantation, one was still in continuous complete remission 83 months later and two had had stable disease for 36 and 37 months while receiving isotretinoin. The authors could not identify any clinical . . . [Full Text of this Article]

References

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• Flotho, C., Kratz, C. P., Bergstrasser, E., Hasle, H., Stary, J., Trebo, M., van den Heuvel-Eibrink, M. M., Wojcik, D., Zecca, M., Locatelli, F., Niemeyer, C. M., on behalf of the European Working Group of Myelody, (2008). Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations. Blood 111: 966-967 [Full Text]  
• Flotho, C., Kratz, C. P., Niemeyer, C. M. (2007). How a rare pediatric neoplasia can give important insights into biological concepts: a perspective on juvenile myelomonocytic leukemia. haematol 92: 1441-1446 [Full Text]  
• Arico, M., Biondi, A., Pui, C.-H. (1997). Juvenile Myelomonocytic Leukemia. Blood 90: 479-488 [Full Text]