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Previous Volume 332:1576-1577 June 8, 1995 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Intracellular signal-transduction pathways have central roles in processes such as growth, development, cellular differentiation, and neurotransmission. Alterations in the levels of various substances involved in signal-transduction pathways have profound effects on cellular functions, and many inherited diseases are caused by mutations that affect key components of signaling pathways.¹

There are two major signal-transduction pathways, one using cyclic AMP (cAMP) and the other diacylglycerol. Each pathway is characterized by its specific protein kinase, protein kinase A and protein kinase C, respectively. The fine modulation of gene expression is achieved by the complex interactions between membrane receptors and the cytoplasmic constituents of . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Weinstein, L. S., Yu, S., Warner, D. R., Liu, J. (2001). Endocrine Manifestations of Stimulatory G Protein {alpha}-Subunit Mutations and the Role of Genomic Imprinting. Endocr. Rev. 22: 675-705 [Abstract] [Full Text]