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Editorial
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Volume 332:1576-1577 June 8, 1995 Number 23
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Signaling Pathways and c-fos Transcriptional Response — Links to Inherited Diseases

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Intracellular signal-transduction pathways have central roles in processes such as growth, development, cellular differentiation, and neurotransmission. Alterations in the levels of various substances involved in signal-transduction pathways have profound effects on cellular functions, and many inherited diseases are caused by mutations that affect key components of signaling pathways.1

There are two major signal-transduction pathways, one using cyclic AMP (cAMP) and the other diacylglycerol. Each pathway is characterized by its specific protein kinase, protein kinase A and protein kinase C, respectively. The fine modulation of gene expression is achieved by the complex interactions between membrane receptors and the cytoplasmic constituents of . . . [Full Text of this Article]

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