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Previous Volume 332:1650-1652 June 15, 1995 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mackall et al. (Jan. 19 issue)¹ clearly demonstrate an inverse relation between age and the ability to regenerate CD4+ populations of T lymphocytes after intensive chemotherapy. They suggest that involution of the thymus (which occurs naturally with age) is likely to account for the diminished capacity to produce CD4+ cells. In the light of what is now known about extrathymic T-cell differentiation, however, the conclusion that "rapid T-cell regeneration requires residual thymic function" cannot be made without first examining CD8+ cell populations, which may have differentiated without a thymic influence. Studies in mice have shown that T-lymphocyte . . . [Full Text of this Article]

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