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Previous Volume 332:1791-1792 June 29, 1995 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Weinblatt, M. E.

To the Editor: Weinblatt discussed the use of methotrexate for chronic diseases in adults (Feb. 2 issue).¹ Although folic acid is helpful in reducing the toxic effects of methotrexate therapy,² its expanded use may have an unintended consequence.

In large doses, folic acid can correct the megaloblastic anemia associated with vitamin B₁₂ deficiency without correcting — and potentially even aggravating — the neurologic abnormalities associated with this deficiency.³ The coexistence of vitamin B₁₂ deficiency and rheumatoid arthritis has been reported.⁴ In patients with Crohn's disease and ileal involvement, vitamin B₁₂ deficiency is not uncommon.⁵

With the increased use of methotrexate . . . [Full Text of this Article]

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