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Correspondence
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Volume 332:270-273 January 26, 1995 Number 4
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Deferoxamine in Thalassemia Major

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 by Brittenham, G. M.
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 by Olivieri, N. F.
To the Editor: Brittenham et al. (Sept. 1 issue)1 have shown that early treatment with deferoxamine in patients with thalassemia major can improve survival and reduce the prevalence of major complications of iron overload (such as cardiac impairment). These findings are also of considerable interest with respect to patients undergoing hemodialysis. Notwithstanding the routine use of erythropoietin in the treatment of uremic anemia, the prevalence of iron-overload complications has been reduced but not eliminated in such patients.

In a group of patients with uremia who were undergo-ing maintenance hemodialysis, we found a prevalence of iron overload of 9.6 percent (14 . . . [Full Text of this Article]

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