Bone is remodeled continuously during adulthood through theresorption of old bone by osteoclasts and the subsequent formationof new bone by osteoblasts. These two closely coupled eventsare responsible for renewing the skeleton while maintainingits anatomical and structural integrity. Under normal conditions,bone remodeling proceeds in cycles in which osteoclasts adhereto bone and subsequently remove it by acidification and proteolyticdigestion. Shortly after the osteoclasts have left the resorptionsite, osteoblasts invade the area and begin the process of formingnew bone by secreting osteoid (a matrix of collagen and otherproteins), which is eventually mineralized. After . . . [Full Text of this Article]
Role of Bone Marrow in Bone-Cell Development
Origin of Osteoblasts
Origin of Osteoclasts
Pathophysiology of Osteoporosis
Bone Remodeling and Osteoporosis
Role of Interleukin-6 in Osteopenia Associated with Loss of Gonadal Function
Loss of Estrogens and Formation of Osteoblast Precursors in Marrow
Senescence and Osteoblast Development in Marrow
Summary
Source Information
From the Division of Endocrinology and Metabolism, Department of Internal Medicine, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, and the McClellan Veterans Affairs Medical Center — both in Little Rock.
Address reprint requests to Dr. Manolagas at the University of Arkansas for Medical Sciences, 4301 W. Markham, Mail Slot 587, Little Rock, AR 72205.
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