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Previous Volume 332:336 February 2, 1995 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The letter "Discordant Occurrence of Primary Biliary Cirrhosis in Monozygotic Twins" (October 6 issue)¹ reflects a common misconception regarding the determination of zygosity. Although the sisters described in the report are twins, inadequate evidence of monozygosity was given. Identifying HLA haplotypes does not establish zygosity. The sisters have the same HLA haplotypes, as do 25 percent of siblings. They are also the same sex, as are 50 percent of dizygotic twins.

Monozygotic twins are formed from a single conceptus and therefore have the same member of each pair of chromosomes from each parent. Testing for concordance for . . . [Full Text of this Article]

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