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Correspondence
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Volume 332:398-400 February 9, 1995 Number 6
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C-Reactive Protein and Serum Amyloid a Protein in Unstable Angina

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 by Liuzzo, G.
To the Editor: In associating the acute-phase reactants C-reactive protein and amyloid A protein with clinical outcome in unstable angina, Liuzzo et al. (Aug. 18 issue)1 provide further evidence that coronary atherosclerosis is an inflammatory disease. However, the importance of their data depends substantially on the acceptance of the view that these reactants are circulating markers of the activity of atherosclerosis and not just indicators of recent myocardial ischemia.

Moreover, whereas the authors find prognostic value in the levels of C-reactive and amyloid A proteins over periods of days to weeks, the plasma concentration of another acute-phase reactant, fibrinogen, has . . . [Full Text of this Article]

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