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Correspondence
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Volume 332:608-610 March 2, 1995 Number 9
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Subforms of Creatine Kinase MB in the Diagnosis of Myocardial Infarction

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 by Hamm, C. W.
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 by Puleo, P. R.
To the Editor: Puleo et al. (Sept. 1 issue)1 conclude that the assay of creatine kinase MB (CK-MB) subforms is superior to the conventional glass-bead assay for CK-MB. The routine CK-MB assay used by these authors is not the conventional assay and was never widely adopted. The sensitivity and analytic specificity of a CK-MB assay contribute substantially to the diagnostic cutoff of the assay and the time required for the assay to become positive. The assays of CK-MB mass using monoclonal antibodies, now in wide use, are highly sensitive and analytically specific for CK-MB, and they detect elevated levels of . . . [Full Text of this Article]

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