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Pseudomonas aeruginosa is a paradigm of the opportunistic pathogen. Over the first four decades of the antimicrobial era, this organism transformed itself from an uncommon and unremarkable pathogen to one of the principal agents of nosocomial infections that cause morbidity and mortality in hospitalized patients. In response to this change, extensive molecular, biologic, clinical, and therapeutic research has been directed toward gaining a better understanding of P. aeruginosa infections. In the past several years, however, P. aeruginosa has been eclipsed by gram-positive organisms as a cause of nosocomial infection and by antimicrobial resistance as a therapeutic problem.
This period
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