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Previous Volume 333:42-44 July 6, 1995 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple myeloma begins when one B cell of approximately 10 billion in the body undergoes mutations that enable it to outgrow most other cells in the bone marrow. When the neoplastic clone consists of 10¹¹ B cells, serum electrophoresis barely detects the clone's signature molecule, a monoclonal immunoglobulin; with 10¹² members, the gammopathy is unmistakable; and with 10¹³ myeloma cells, symptoms begin to appear. Not the least of the clinical problems in patients with myeloma is susceptibility to bacterial infection, a paradox given the huge amounts of gamma globulin secreted by the tumor. But most of the antibodies in the . . . [Full Text of this Article]

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