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Previous Volume 333:710-714 September 14, 1995 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The concept of oxygen as a therapeutic agent was introduced in the 1920s by Alvin Barach.¹ Since then, a better understanding of the effects of hypoxemia, and of their reversal with oxygen supplementation, has enhanced the treatment of patients with pulmonary diseases. There are close to 800,000 patients receiving long-term oxygen therapy in the United States, at a yearly cost of $1.8 billion.^2,3 We need to understand the effects of oxygen therapy, the indications for it, and its modes of delivery in order to make the most appropriate use of this effective therapeutic resource. In this article, we discuss long-term . . . [Full Text of this Article]

Physiologic Responses to Hypoxemia

Effects of Long-Term Oxygen Therapy

Survival

Pulmonary Hemodynamics

Exercise Capacity

The Work of Breathing

Neuropsychological Effects

Sleep

Determining the Need for Oxygen

Prescribing Oxygen

Systems of Oxygen Delivery

Misconceptions and Hazards

Oxygen-Administration Devices

Future Directions

Source Information

From the Pulmonary Center, Boston University School of Medicine (S.P.T.), and St. Elizabeth's Medical Center and Tufts University School of Medicine (B.R.C.) — all in Boston.

Address reprint requests to Dr. Celli at the Department of Pulmonary and Critical Care, St. Elizabeth's Medical Center, 736 Cambridge St., Boston, MA 02135.

References

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