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Previous Volume 333:732-733 September 14, 1995 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Becker's muscular dystrophy and Duchenne's muscular dystrophy are allelic disorders caused by mutations of the dystrophin gene at Xp21.¹ The 400-kd dystrophin is expressed most abundantly in the plasma membranes of skeletal and cardiac muscle fibers but is absent in patients with severe Duchenne's muscular dystrophy and in mdx mice. The expression of a truncated, "semifunctional" dystrophin molecule is usually associated with Becker's muscular dystrophy, which is milder than Duchenne's muscular dystrophy.²

It is not clear whether the full-length dystrophin molecule induces a specific immune response against the deleted sequence in a patient with Becker's muscular dystrophy. . . . [Full Text of this Article]

References

This article has been cited by other articles:

• EBIHARA, S., GUIBINGA, G.-H., GILBERT, R., NALBANTOGLU, J., MASSIE, B., KARPATI, G., PETROF, B. J. (2000). Differential effects of dystrophin and utrophin gene transfer in immunocompetent muscular dystrophy (mdx) mice. Physiol. Genomics 3: 133-144 [Abstract] [Full Text]