To the Editor: An apparently new human herpesvirus, designatedKaposi's sarcomaassociated herpesvirus (KSHV) or humanherpesvirus 8, has recently been identified in samples of Kaposi'ssarcoma from patients infected with the human immunodeficiencyvirus (HIV).1 In the May 4 issue of the Journal, Moore and Chang2reported finding KSHV DNA in samples of Kaposi's sarcoma frompatients without HIV infection, and Cesarman et al.3 describedfinding KSHV DNA in an unusual high-grade body-cavitybasedlymphoma in HIV-infected patients. The lymphoma shows a strongtendency toward primary involvement of body-cavity surfaceswithout local or distant spread to other viscera.4
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