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Correspondence
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Volume 333:802 September 21, 1995 Number 12
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Prevention and Treatment of the Complications of Diabetes Mellitus

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To the Editor: In their excellent review of the complications of diabetes mellitus (May 4 issue),1 Drs. Clark and Lee recommend amitriptyline as the tricyclic drug of choice for the treatment of symptomatic peripheral neuropathy, stating that this agent was "clearly more effective in relieving pain than desipramine" in a study by Max et al.2 Contrary to this statement, Max et al. did not find a statistically significant difference between desipramine and amitriptyline in relieving pain due to diabetic neuropathy, although amitriptyline tended to provide slightly greater relief than desipramine, on the basis of pain-diary scores. This distinction is important, . . . [Full Text of this Article]

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