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Correspondence
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Volume 333:802-803 September 21, 1995 Number 12
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Hydroxyurea in Essential Thrombocytosis

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 by Cortelazzo, S.
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 by Clark, C. M.
To the Editor: Although the study of Cortelazzo and colleagues (April 27 issue)1 was not designed to assess the role of antiplatelet drugs in preventing vascular thrombotic complications of essential thrombocythemia, the authors note that the relative risk of thrombosis was not significantly reduced by treatment with these drugs. Because 70 percent of the hydroxyurea group and 69 percent of the control group received antiplatelet drugs (aspirin and ticlopidine), the lack of reduction in risk with these drugs merely reflects adequate randomization rather than the lack of a favorable effect of antiplatelet drugs on the incidence of thrombosis. In several . . . [Full Text of this Article]

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