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Previous Volume 333:811-815 September 21, 1995 Number 12

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Two and a half years ago, when I was still a private citizen working at the University of California, San Francisco, my colleagues, Mike Bishop and Marc Kirschner, and I offered advice to our new President in Science magazine.¹ The first of our 11 recommendations was to increase funding for the National Institutes of Health (NIH) by 15 percent per year, in order to double the NIH budget in five years and restore the success rate for grant applications to at least 30 percent. A year later, just after I had been called to Washington to work for that President . . . [Full Text of this Article]

The Historical Context

Benefits of Four Decades of NIH Growth

Changes in Federal Support

Recognizing the Steady State

Accommodating to the Steady State

Combating the Negative State

Some Arguments for NIH Funding

A Modest Proposal for the NIH

Source Information

Presented as the 105th Shattuck Lecture to the Annual Meeting of the Massachusetts Medical Society, Boston, May 20, 1995.

Address reprint requests to Dr. Varmus at the National Institutes of Health, Bldg. 1, Rm. 126, 1 Center Dr., MSC 0148, Bethesda, MD 20892-0148.

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