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Correspondence
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Volume 333:877-878 September 28, 1995 Number 13
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Treatment of Unresectable Hepatocellular Carcinoma

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 by Tsukuma, H.
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 by Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire
To the Editor: In a group of patients with unresectable hepatocellular carcinoma but without severe liver disease, Trinchet et al. (May 11 issue)1 found that chemoembolization with Lipiodol (iodized oil) reduced tumor growth, often caused acute liver failure, and did not significantly improve survival. Because of variations in protocols and in the levels of expertise with which chemoembolization is performed, the authors' conclusion that this therapy should not be recommended may not be applicable to many patients.

Regardless of the exact method used, there will be some degree of hepatic damage after embolization, and this accumulated injury following repeated chemoembolizations . . . [Full Text of this Article]

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