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Previous Volume 333:943-944 October 5, 1995 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is an acyclic nucleoside phosphonate analogue with broad-spectrum antiviral activity against DNA viruses, including herpesviruses (herpes simplex virus, varicella–zoster virus, cytomegalovirus, and Epstein–Barr virus), adenoviruses, poxviruses, and papillomaviruses.^1,2 We recently showed that local injections of HPMPC into a life-threatening squamous papilloma of the hypopharynx–esophagus eradicated the tumor.² Two years later, the patient was still free of disease. We report the use of HPMPC in three patients with AIDS and severe, relapsing anogenital human papillomavirus lesions.

A 44-year-old homosexual man had been unsuccessfully treated for recurrent penile human papillomavirus lesions since December 1993 with curettage and . . . [Full Text of this Article]

References

This article has been cited by other articles:

• De Clercq, E. (2003). Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections. Clin. Microbiol. Rev. 16: 569-596 [Abstract] [Full Text]  
• Johnson, J. A., Gangemi, J. D. (2003). Alpha Interferon Augments Cidofovir's Antiviral and Antiproliferative Activities. Antimicrob. Agents Chemother. 47: 2022-2026 [Abstract] [Full Text]  
• Volberding, P. A., Baker, K. R., Levine, A. M. (2003). Human Immunodeficiency Virus Hematology. ASH Education Book 2003: 294-313 [Abstract] [Full Text]  
• Gyulai, R., Kemeny, L., Kiss, M., Adam, E., Nagy, F., Dobozy, A. (1996). Herpesvirus-Like DNA Sequence in Angiosarcoma in a Patient without HIV Infection. NEJM 334: 540-541 [Full Text]  
• Hermine, O., Michel, M., Buzyn-Veil, A., Gessain, A., Cesarman, E., Nador, R., Knowles, D. M. (1996). Body-Cavity-Based Lymphoma in an HIV-Seronegative Patient without Kaposi's Sarcoma-Associated Herpesvirus-Like DNA Sequences. NEJM 334: 272-273 [Full Text]