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Previous Volume 333:1080-1081 October 19, 1995 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the Clinical Problem-Solving case presented by Dr. Duffy (June 1 issue),¹ concerning a patient with hemolytic anemia due to cold agglutinins who later received a diagnosis of large-cell lymphoma, there was a failure to probe for an important pathogenetic link that might have led to more rational and effective therapy. Serum electrophoretic and immunofixation studies in patients with cold-agglutinin anemia and lymphoma usually reveal a monoclonal immunoglobulin of the IgM type, and in rare cases of the IgG or IgA type.²

Coupled with phenotypic studies of lymphoma tissue (i.e., heavy and light chains and CD5 expression), . . . [Full Text of this Article]

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