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Previous Volume 333:1145-1146 October 26, 1995 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.¹ Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth are available and many biochemical tests are performed.² Although the difficulties can be attributed at least in part to the pulsatile secretion of GH and the vagaries of GH assays, they also reflect the complex relation between GH and the insulin-like growth factor (IGF) axis. To be biologically active, GH must bind to a transmembrane receptor, the receptor must form a dimer, and an . . . [Full Text of this Article]

References

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• Rosenfeld, R. G., Hwa, V. (2004). Toward a Molecular Basis for Idiopathic Short Stature. J. Clin. Endocrinol. Metab. 89: 1066-1067 [Full Text]  
• Buckway, C. K., Selva, K. A., Pratt, K. L., Tjoeng, E., Guevara-Aguirre, J., Rosenfeld, R. G. (2002). Insulin-Like Growth Factor Binding Protein-3 Generation as a Measure of GH Sensitivity. J. Clin. Endocrinol. Metab. 87: 4754-4765 [Abstract] [Full Text]  
• Buckway, C. K., Guevara-Aguirre, J., Pratt, K. L., Burren, C. P., Rosenfeld, R. G. (2001). The IGF-I Generation Test Revisited: A Marker of GH Sensitivity. J. Clin. Endocrinol. Metab. 86: 5176-5183 [Abstract] [Full Text]  
• TRIPPEL, S. B., COUTTS, R. D., EINHORN, T. A., MUNDY, G. R., ROSENFELD, R. G. (1996). Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Growth Factors as Therapeutic Agents*{{dagger}}. JBJS 78: 1272-86 [Full Text]