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Previous Volume 333:1260-1267 November 9, 1995 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Maintenance of a constant volume in the face of extracellular and intracellular osmotic perturbations is a critical problem faced by all cells. Most cells respond to swelling or shrinkage by activating specific metabolic or membrane-transport processes that return cell volume to its normal resting state. These processes are essential for the normal function and survival of cells. This article will outline the cellular and molecular events underlying cell-volume homeostasis and discuss their relevance to medical practice.

Fundamentals of Cell-Volume Regulation

Meeting Osmotic Challenges

Water is in thermodynamic equilibrium across the plasma membrane. In other words, the osmotic concentrations of cytoplasmic and extracellular fluids are equal under steady-state . . . [Full Text of this Article]

Electrolyte Transport and Volume Regulation

Organic Osmolytes

Sensing Cell Size

Cell-Volume Homeostasis and Pathophysiology

Rapid Regulatory Volume Increase in the Brain — Defeating Osmotherapy

Correction of Plasma Hypertonicity — Undermining Nature

Disruption of Cellular Osmoregulation — Complications of Diabetes Mellitus

Sickle Cell Crisis — Blocking Capillaries by Shrinking Cells

Cellular Proliferation — Volume as a Signal

Conclusions

Source Information

From the Critical Care Research Laboratories, Departments of Anesthesia (M.L.M., K.B.C., K.S.) and Medicine (Nephrology) (K.S.), Children's Hospital and Harvard Medical School, Boston.

Address reprint requests to Dr. McManus at Children's Hospital, Department of Anesthesia, MICU Office, Farley 517, Boston, MA 02115.

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