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Editorial
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Volume 333:123-124 July 13, 1995 Number 2
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What Causes Wasting in AIDS?

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The wasting syndrome, defined as the unintentional loss of more than 10 percent of body weight, is a devastating complication of AIDS, other infections, and cancer.1 Because weight loss is an independent contributor to death,2,3 reversing it could theoretically both extend life and improve its quality.

Unfortunately, nutritional supplementation is not uniformly effective in patients with the wasting syndrome.1 Such supplementation does improve the nitrogen balance in patients with carcinoma of the esophagus and stomach in whom food intake is decreased. In patients with lymphoma or patients with AIDS who have active infections, hyperalimentation increases fat mass but not lean . . . [Full Text of this Article]

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