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Correspondence
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Volume 333:126-127 July 13, 1995 Number 2
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Povidone-Iodine to Prevent Ophthalmia Neonatorum

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 by Foster, A.
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 by Isenberg, S. J.
To the Editor: Isenberg and colleagues (March 2 issue)1 demonstrated the effectiveness of povidone-iodine prophylaxis against ophthalmia neonatorum but limited their observation of side effects to local toxic reactions. Were the systemic effects of povidone-iodine, such as alterations in thyroid metabolism, evaluated in a pilot study?

Topical application of povidone-iodine has been known to cause transient hypothyroidism in newborns as a result of iodine excess.2 Iodine-induced hyperthyroidism has also been described in a newborn exposed to large doses of iodine.3 Although probably unimportant in most cases, the systemic effects of the conjunctival application of povidone-iodine should be thoroughly evaluated before . . . [Full Text of this Article]

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