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Correspondence
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Volume 333:129-130 July 13, 1995 Number 2
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Gastrointestinal Cancer and the Cystic Fibrosis Gene

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 by Neglia, J. P.
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To the Editor: Neglia et al. (Feb. 23 issue)1 report an increased incidence of gastrointestinal cancer in patients with cystic fibrosis and suggest a relation between the action of the defective gene and the development of cancer in the gastrointestinal tract. If this relation is confirmed, the gene for cystic fibrosis may be added to the growing list of genes conferring an increased risk of cancer and may be the first example of a more widespread biologic phenomenon: the role of evolutionary biology in cancer genetics.

Since 1 in 25 to 50 white persons carries the gene for cystic fibrosis, . . . [Full Text of this Article]

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