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Previous Volume 333:1508-1509 November 30, 1995 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Graudins et al. (July 20 issue)¹ report a case of an overdose of extended-release acetaminophen (Tylenol Extended Relief, McNeil Pharmaceuticals). We would like to provide additional information to help physicians evaluate such cases.

With regard to the formulation, Tylenol Extended Relief is a bilayered extended-release caplet containing a total of 650 mg of acetaminophen. One side of the caplet contains 325 mg of immediate-release acetaminophen. The other side contains a matrix formulation of 325 mg of acetaminophen designed to be released more slowly. In vitro, 2 caplets containing a total of 1.3 g of acetaminophen release 88 . . . [Full Text of this Article]

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