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Previous Volume 333:1570-1572 December 7, 1995 Number 23 Next

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To the Editor: Lipid-lowering drugs are generally expensive and frequently have bothersome side effects. Although primary-prevention trials have shown that lipid-lowering therapy can reduce the incidence of coronary heart disease in middle-aged men, meta-analysis of these trials has shown no effect of this type of therapy on overall survival.¹ Concern about serious adverse effects of lipid-lowering drugs has prompted some to urge caution in their use in healthy, asymptomatic people.²

Although the Journal's recent review of primary prevention of coronary heart disease in women (June 29 issue)³ does not directly advocate the use of lipid-lowering drugs in women, we . . . [Full Text of this Article]

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