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Editorial
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Volume 333:1633-1635 December 14, 1995 Number 24
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Is There an Inherited General Susceptibility to Cancer?

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In the past few years, studies in molecular genetics have improved our understanding of familial cancer and enriched our knowledge of carcinogenesis. In one kind of familial cancer, the same specific type of cancer occurs in excess, usually at a younger age than in the general population.1 Some types are rare cancers with mendelian inheritance — for example, bilateral retinoblastoma in childhood and early colon cancer in familial adenomatous polyposis. Other cancers are more common, such as breast, ovarian, and colon cancers, which may, but usually do not, aggregate in families. In another kind of familial cancer, different types of . . . [Full Text of this Article]

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