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Previous Volume 333:1783-1784 December 28, 1995 Number 26 Next

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To the Editor: Mutations at various gene loci have recently been shown to cause the long-QT syndrome,^1,2 as Towbin (Aug. 10 issue)³ reports. We have studied one of these loci, the human ether-a-go-go–related gene (HERG, the gene for the long-QT syndrome 2, or LQT2, on chromosome 7), by direct sequencing of the major functional regions between the expressed S1 domain and the cyclic-nucleotide–binding domain in 15 patients with the long-QT syndrome. This sequencing resulted in the identification of two new mutations in a highly conserved region of HERG. One patient had a single base-pair deletion (delT1671, with the . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Towbin, J. A., Wang, Z., Li, H. (2001). Genotype and Severity of Long QT Syndrome. Drug Metab. Dispos. 29: 574-579 [Abstract] [Full Text]  
• Splawski, I., Shen, J., Timothy, K. W., Lehmann, M. H., Priori, S., Robinson, J. L., Moss, A. J., Schwartz, P. J., Towbin, J. A., Vincent, G. M., Keating, M. T. (2000). Spectrum of Mutations in Long-QT Syndrome Genes : KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102: 1178-1185 [Abstract] [Full Text]  
• Chiang, C.-E., Roden, D. M. (2000). The long QT syndromes: genetic basis and clinical implications. J Am Coll Cardiol 36: 1-12 [Abstract] [Full Text]  
• Nakajima, T., Furukawa, T., Hirano, Y., Tanaka, T., Sakurada, H., Takahashi, T., Nagai, R., Itoh, T., Katayama, Y., Nakamura, Y., Hiraoka, M. (1999). Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2. Cardiovasc Res 44: 283-293 [Abstract] [Full Text]  
• Chen, J., Zou, A., Splawski, I., Keating, M. T., Sanguinetti, M. C. (1999). Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation. J. Biol. Chem. 274: 10113-10118 [Abstract] [Full Text]  
• Nakajima, T., Furukawa, T., Tanaka, T., Katayama, Y., Nagai, R., Nakamura, Y., Hiraoka, M. (1998). Novel Mechanism of HERG Current Suppression in LQT2 : Shift in Voltage Dependence of HERG Inactivation. Circ. Res. 83: 415-422 [Abstract] [Full Text]  
• Tanaka, T., Nagai, R., Tomoike, H., Takata, S., Yano, K., Yabuta, K., Haneda, N., Nakano, O., Shibata, A., Sawayama, T., Kasai, H., Yazaki, Y., Nakamura, Y. (1997). Four Novel KVLQT1 and Four Novel HERG Mutations in Familial Long-QT Syndrome. Circulation 95: 565-567 [Abstract] [Full Text]