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Correspondence
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Volume 333:192-193 July 20, 1995 Number 3
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Interleukin-2 as Therapy for HIV Disease

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 by Kovacs, J. A.
To the Editor: The article by Kovacs et al. on interleukin-2 therapy in patients with human immunodeficiency virus (HIV) infection (March 2 issue)1 highlights the dilemma that this disease poses: how to get rid of a virus whose replication is enhanced by activation of the immune system.

The increase in the HIV RNA level after an infusion of interleukin-2 was most consistent in patients with CD4 counts of 200 or fewer cells per cubic millimeter. In this group, interleukin-2 was associated with "few immunologic improvements, and substantial toxic effects," but increased levels of HIV RNA were also observed in patients . . . [Full Text of this Article]

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