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Previous Volume 333:194-195 July 20, 1995 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The report by Kaufmann et al. (Feb. 23 issue)¹ on the remarkable clinical course of a patient with mantle-cell lymphoma offered an ingenious explanation for the recurrent spontaneous remissions they observed. However, their demonstration of apoptosis in circulating lymphoma cells during the early phase of the remissions leaves unanswered the question whether the trigger mechanism was intrinsic or extrinsic to the tumor cells. We suggest that an undulating T-cell–mediated immune response against lymphoma cells may have been involved. We analyzed a similar case in which a patient with anaplastic large-cell lymphoma had repeated spontaneous remissions. We found . . . [Full Text of this Article]

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