In the dozen years since the genetics of human cancer was firstreviewed in these pages, we have achieved an understanding ofthe processes governing cell growth and differentiation thatis quite sophisticated, but we still have far to go. For eachcellular gene then implicated in the control of growth, at leasta dozen more have joined the list. We have also added severalconcepts, entirely new and elemental, to our view of how cellsenter the proliferative state and then leave it, either to undertakespecialized tasks or to die. These advances have revolutionizedthe diagnosis and prognosis . . . [Full Text of this Article]
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From the Department of Medicine, New England Medical Center, 750 Washington St., Boston, MA 02111, where reprint requests should be addressed to Dr. Krontiris.
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