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Previous Volume 333:325-326 August 3, 1995 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The mechanism of the analgesia resulting from transcutaneous electrical nerve stimulation (TENS) is not clear. A possible mediator of TENS analgesia is adenosine, formed from adenosine triphosphate released from the large primary afferent fibers that are selectively recruited by TENS.^1,2 Moreover, the inhibitory effect of vibration, which also activates these afferents, on nociceptive neurons in the spinal cord is blocked by the adenosine-receptor antagonist caffeine.¹

Using a double-blind protocol, we investigated the effect of 200 mg of caffeine and 200 mg of placebo, given orally in random order one week apart, on the perception of intensity and . . . [Full Text of this Article]

References

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