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Correspondence
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Volume 333:390-391 August 10, 1995 Number 6
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More on Subforms of Creatine Kinase MB

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 by Puleo, P. R.
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To the Editor: Puleo et al. (Sept. 1 issue)1 described the use of a rapid test of subforms of creatine kinase MB (CK-MB) to diagnose myocardial infarction earlier than was previously thought to be possible. This report is of obvious importance, since the authors claim a potential reduction of about 70 percent in admissions to coronary care units. The assay is based on measuring the ratio of CK-MB2 (the subform containing C-terminal lysine) to CK-MB1 (the des-lysine subform), for which the normal cutoff value is 1.5. CK-MB2 released from the damaged myocardium is converted to CK-MB1 in the blood by . . . [Full Text of this Article]

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