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Previous Volume 333:426-429 August 17, 1995 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The X-linked hyper-IgM syndrome is a rare immunodeficiency disease in which the ability of B cells to switch immunoglobulin production from IgM to IgG, IgA, and IgE is defective.¹ A variety of mutations of the gene encoding the CD40 ligand cause the immunodeficiency.^2,3,4,5,6 The functional effect of the mutation is that the CD40 ligand on T cells cannot interact with the CD40 glycoprotein on the surface of B cells. This interaction normally mediates immunoglobulin class switching by B cells. The deficiency of IgG and IgA leads to recurrent infections of the respiratory tract that can be prevented by intravenous immune . . . [Full Text of this Article]

Case Report

Methods

Results

Discussion

Source Information

From the Unité d'Immunohématologie (C.T., M.B., E.H., S.B., A.F.), INSERM Unité 429 (G.S.B., F.L.D., A.F.), and the Laboratoire de Cytogénétique, Hôpital des Enfants-Malades (D.T.) — all in Paris.

Address reprint requests to Dr. Fischer at INSERM Unité 429, Hôpital Necker, 149 Rue de Sevres, 75015 Paris, France.

References

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