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Volume 333:520-521 August 24, 1995 Number 8
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Clinical Problem-Solving: We Blew It

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To the Editor: Dr. Kreisberg (April 6 issue)1 makes the ex-cellent clinical point that deciphering liver conditions is difficult in patients with AIDS. I am a little skeptical about viewing trimethoprim–sulfamethoxazole as the sole problem in the case presented. According to the case history, the patient consumed alcohol regularly, albeit in amounts that were apparently modest. The ratio of aspartate aminotransferase to alanine aminotransferase was more than 3:1, a finding that is common in patients with alcoholic hepatitis rather than drug-induced hepatitis. Admittedly, the levels are higher than those that alcoholic hepatitis typically causes. Therefore, I would hypothesize that there . . . [Full Text of this Article]

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