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Previous Volume 333:521-522 August 24, 1995 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lipton and Gendelman ascribe a key role to macrophages and reactive oxygen intermediates in the pathogenesis of dementia associated with human immunodeficiency virus (HIV) infection (April 6 issue).¹ Since inhibi-tors of nitric oxide synthase were found to prevent gp120-induced neurotoxic effects in vitro, the authors speculate that nitric oxide triggers neurologic damage. However, it is questionable whether macrophages from humans, unlike those from other species, can produce relevant amounts of nitric oxide. Other cells in the brain, such as astrocytes, could be a source of nitric oxide, but there is no evidence of enhanced formation of nitric . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Klein, R. S., Williams, K. C., Alvarez-Hernandez, X., Westmoreland, S., Force, T., Lackner, A. A., Luster, A. D. (1999). Chemokine Receptor Expression and Signaling in Macaque and Human Fetal Neurons and Astrocytes: Implications for the Neuropathogenesis of AIDS. J. Immunol. 163: 1636-1646 [Abstract] [Full Text]