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Correspondence
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Volume 333:601-602 August 31, 1995 Number 9
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Maternal–Fetal Transfer of Octreotide

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To the Editor: Octreotide, a long-acting analogue of somatostatin, is effective therapy for patients with thyrotropin (TSH)-secreting pituitary adenomas.1 A 31-year-old infertile woman with hyperthyroidism caused by a TSH-secreting macroadenoma was treated with a continuous subcutaneous infusion of 300 µg of octreotide per day. She became euthyroid, and the macroadenoma decreased in size, as determined by magnetic resonance imaging (MRI). Subsequently, the woman was found to be pregnant, and therefore octreotide treatment was stopped at one month of gestation.2,3 At six months of gestation she was again hyperthyroid, her serum TSH concentration was elevated, visual-field examination was abnormal, and MRI . . . [Full Text of this Article]

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