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Review Article
Mechanisms of Disease
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Volume 334:28-33 January 4, 1996 Number 1
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Transcription-Factor Mutations and Disease
David S. Latchman, D.Sc.

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Correct regulation of gene expression, so that specific proteins are made by the appropriate organs at the appropriate times or in response to specific signals, is essential both to normal development and to the correct functioning of the adult organism. Such regulation is usually achieved at the level of DNA transcription, a process that controls which genes are transcribed into RNA by the enzyme RNA polymerase, although regulation also occurs after transcription.1

The transcription of specific genes is controlled by regulatory proteins known as transcription factors.2,3 These factors therefore have a vital function in both embryonic development and the response . . . [Full Text of this Article]

Developmental Disorders

Disorders of Hormone Response

Oncogenic Transcription Factors and Cancer

Antioncogenic Transcription Factors and Cancer

Prospects for Therapy


Source Information

From the Department of Molecular Pathology, University College London Medical School, Windeyer Bldg., Cleveland St., London W1P 6DB, United Kingdom, where reprint requests should be addressed to Professor Latchman.

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