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Correspondence
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Volume 334:55-56 January 4, 1996 Number 1
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Oral Ganciclovir for Cytomegalovirus Retinitis

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 by Drew, W. L.
To the Editor: We are troubled by the strong conclusion of Drew et al. (Sept. 7 issue)1 that "oral ganciclovir is safe and effective as maintenance therapy for cytomegalovirus retinitis." This statement implies equivalence between intravenous and oral ganciclovir, which we believe is not convincingly supported by the data.

When there is no difference between the treatment groups, one does not accept the null hypothesis but rather fails to reject it. In other words, if the data show there is no difference between intravenous and oral ganciclovir, it does not imply they are equivalent but rather that there is not . . . [Full Text of this Article]

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