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Previous Volume 334:630-633 March 7, 1996 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Autoimmunity is often implicated in pure red-cell aplasia. Approximately 10 to 15 percent of patients with pure red-cell aplasia have thymomas,¹ and remission of the anemia occurs in 25 to 30 percent of these patients after the thymoma is removed.² In other patients there are immunologic abnormalities, such as hypogammaglobulinemia,³ monoclonal immunoglobulins,⁴ antithyroid antibodies,⁵ antinuclear antibodies,^6,7 and autoimmune hemolytic anemia.^3,8 Immunosuppressive therapy is successful in many patients,^2,9,10,11,12 and a good response to plasmapheresis has been reported in two patients.^13,14

In 1967 Krantz and Kao reported that plasma from a patient with pure red-cell aplasia inhibited heme synthesis by normal bone . . . [Full Text of this Article]

Case Report

Methods

Bone Marrow Cultures

Measurement of Serum Erythropoietin

Binding of ¹²⁵I-Labeled Erythropoietin

Deglycosylation Studies

Results

Discussion

Source Information

From the Department of Hematology, Hôpital R. Poincaré, Garches (N.C.); the Department of Hematology, Hôpital Lariboisière, Paris (E.D., P.M.-S., G.T.); the Department of Hematology, Hôpital Necker, Paris (B.V.); INSERM Unité 362, Villejuif (N.C.); and Institut Cochin de Génétique Moléculaire, INSERM Unité 363, Paris (P.M.) — all in France.

Address reprint requests to Dr. Casadevall at the Department of Hematology, Hôpital R. Poincaré, 104 Blvd. Raymond Poincaré, 92 380 Garches, France.

References

Related Letters:

Antibodies against Recombinant Human Erythropoietin in a Patient with Erythropoietin-Resistant Anemia
Peces R., de la Torre M., Alcázar R., Urra J. M.
Extract | Full Text  
N Engl J Med 1996; 335:523-524, Aug 15, 1996. Correspondence

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