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Previous Volume 334:653-654 March 7, 1996 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The photograph of a giant transgenic mouse created by the overexpression of growth hormone, which appeared on the cover of Nature in 1982, represented a landmark in molecular biology. The technology for producing transgenic animals was made possible by the coalescence of fundamental discoveries in several disciplines over a period of decades. These discoveries led to important insights into the hormonal control of reproduction in mammals and the development of techniques to harvest, manipulate, and reimplant eggs and early embryos — techniques that are used today by in vitro fertilization clinics throughout the world. Another important development was the use . . . [Full Text of this Article]

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From the Division of Gerontology and Geriatric Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Cir., Rm. 5A42, Baltimore, MD 21224, where reprint requests should be addressed to Dr. Shuldiner.

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