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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 334:715-721 March 14, 1996 Number 11
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Case 8-1996— A 28-year-old woman with the rapid development of a major personality change and global aphasia
K. Stefansson, and E.T. Hedley-Whyte

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Presentation of Case

A 28-year-old woman was admitted to the hospital because of the rapid development of a major personality change and global aphasia.

The patient had been well until one month earlier, when she reported an intermittent toothache in the left upper molar region, accompanied by diffuse, severe headaches, which resolved after three weeks. One week before admission, she had nausea and vomiting after eating "bad food." Two days later she was unusually quiet and withdrawn and sounded intoxicated, although she said she had not been drinking. Three days before admission, her speech was abnormal, and she appeared giddy and frequently laughed . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnoses

Dr. Kari Stefansson's Diagnosis

Pathological Discussion

Anatomical Diagnosis

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