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Previous Volume 334:736-737 March 14, 1996 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Using molecular evidence, Hamilton et al. (March 30 issue)¹ defined two germ-line defects associated with Turcot's syndrome, one of which is usually found in hereditary nonpolyposis colorectal cancer, and the other of which is usually found in familial adenomatous polyposis. The former defect is characterized by mutations in mismatch-repair genes, which lead to widespread microsatellite instability. Exceptional survival rates of more than three years have been reported in three patients with glioblastoma linked to the form of Turcot's syndrome characterized by colorectal cancer,¹ whereas the expected median survival rate is about eight months.² Thus, the question arises . . . [Full Text of this Article]

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